The Bahay Nakpil-Bautista is located across the Quiapo Church. This house was bult by Dr. Ariston Bautista, who discovered a drug against cholera, and wife Petrona Nakpil. They are friends of Philippine National Hero, Dr. Jose Rizal. Gregoria de Jesus, the widow of Andres Bonifacio who is also a Philippine Hero, also lived in this house. The Bahay Nakpil-Bautista is one of the best examples of Philippine architecture.